- Ipsilateral Synchronous Renal Cell Carcinoma and Transitional Cell Carcinoma: A Case Report.
-
Ji Young Park, Eun Kyung Kwak, Tae In Park
-
Korean J Pathol. 2002;36(6):429-432.
-
-
-
 Abstract
 PDF
- We report a synchronous renal cell carcinoma (RCC) and renal pelvic transitional cell carcinoma (TCC) in the kidney of a 74-year-old man. The kidney was without hydronephrosis. The patient was admitted to the hospital because he had intermittent gross hematuria for three years.
Histologically, a section of the specimen revealed a conventional (clear cell) RCC in renal parenchyma just beneath the renal pelvis and a papillary urothelial carcinoma arising from the renal pelvis at the upper pole; the two are completely separated from one another. The tumor cells of the TCC showed an overexpression of c-MET immunohistochemical staining and more intense positive reactivity for p53 immunohistochemical staining than those of the RCC. These findings suggest that c-Met and p53 may be associated with the development of papillary TCC.
- Molecular Diagnosis of Cutaneous T Cell Lymphoproliferative Diseases.
-
Ji Young Park, Myung Hoon Lee, Eun Kyung Kwak, Dong Ja Kim, Tae In Park, Han Ik Bae
-
Korean J Pathol. 2000;34(11):941-949.
-
-
-
Abstract
PDF
- It is often problematic to diagnose T-cell lymphoproliferative disorders of the skin because of the difficulty in establishing clonality in paraffin-embedded tissue. We used polymerase chain reaction single strand conformational polymorphism (PCR-SSCP) and heteroduplex analysis in paraffin embedded tissue to detect clonal rearrangement of T-cell receptor gamma (TCRgamma) gene in 17 T-cell lymphoproliferative disorders and 6 atypical lymphoproliferative diseases. We used polymerase chain reaction to detect TCR beta gene rearrangement in 8 of 17 cases which did not show TCRgamma gene rearrangement.
Jurkat cell lines were used as monoclonal controls. DNA was extracted from 5 biopsies of T-cell lymphomas, 10 biopsies of mycosis fungoides, 2 biopsies of lymphomatoid papulosis, and 6 biopsies of atypical lymphoproliferative lesions. We detected monoclonality in 5 of 5 T-cell lymphoma cases, 2 of 2 lymphomatoid papulosis cases, 6 of 10 mycosis fungoides cases, and 2 of 6 atypical lymphoproliferative disease cases. We conclude that nonradioactive PCR-SSCP for TCR gene rearrangement analysis is a useful adjunct to routine histological and immunophenotypic methods in the diagnosis of cutaneous T cell lymphoproliferative disorders in paraffin embedded tissue.
|
E-submission
